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Mesotherapy, a cosmetic procedure involving the injection of various substances into the skin, has recently surged in popularity, particularly among individuals seeking non-surgical solutions for aesthetic concerns such as under-eye bags, cellulite, and localized fat deposits. Despite its growing appeal, medical professionals are raising alarms about the potential risks associated with this treatment, especially when performed by untrained individuals or in non-clinical settings.​

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Originally developed in 1952 by French physician Dr. Michel Pistor, mesotherapy was intended to treat vascular and lymphatic disorders. Over time, its application expanded into the cosmetic realm, where it is now used to address a variety of concerns, including skin rejuvenation, fat reduction, and hair loss. The procedure involves injecting a concoction of vitamins, enzymes, hormones, and plant extracts into the mesoderm, the middle layer of the skin, with the aim of improving circulation and breaking down fat cells.​

The advent of social media platforms like TikTok has played a significant role in popularizing mesotherapy, with numerous influencers showcasing their experiences and results. This exposure has led to a surge in DIY mesotherapy kits and at-home treatments, often performed without proper medical supervision. Such practices have prompted concerns among healthcare professionals regarding the safety and efficacy of unsupervised procedures.​

Dr. Viktoryia Kazlouskaya, a dermatologist based in New York, has cautioned against the unsupervised use of mesotherapy, particularly for under-eye treatments. She notes that patients may experience adverse effects such as prolonged bruising, severe allergic reactions, skin necrosis due to inadvertent injection into blood vessels, and even permanent eye damage. ​

Further compounding the issue is the lack of standardized formulations in mesotherapy. Practitioners often use personalized mixtures, the contents of which can vary widely and may include prescription medications, increasing the risk of unexpected side effects. ​

In the United States, the Food and Drug Administration (FDA) has not approved any specific substances for use in mesotherapy. While some components used in the injections may have FDA approval for other indications, their use in mesotherapy is considered off-label. This regulatory gap means that the safety and efficacy of mesotherapy treatments are not guaranteed, and patients may be exposed to unverified products. ​

Similarly, in the United Kingdom, mesotherapy is not directly regulated by law. However, the government is currently consulting on a new licensing scheme for non-surgical cosmetic procedures, which would likely encompass mesotherapy. ​

While mesotherapy is often marketed as a minimally invasive and low-risk procedure, several side effects have been reported, particularly when performed improperly. Common adverse reactions include:​

  • Swelling and bruising: Due to needle trauma and the introduction of foreign substances.​
  • Redness and irritation: As a result of the body’s immune response.​
  • Pain or discomfort: At the injection sites.​
  • Infection: Especially when performed in non-sterile environments.​
  • Allergic reactions: To components within the injection mixture.​
  • Skin discoloration: Temporary or permanent changes in pigmentation.​
  • Ulceration and panniculitis: Rare but serious conditions involving tissue damage and inflammation. ​

Medical experts emphasize the importance of consulting qualified healthcare professionals before undergoing mesotherapy. Proper patient assessment, sterile techniques, and the use of approved substances are crucial in minimizing risks. Patients are advised to avoid at-home treatments and to be wary of unlicensed practitioners offering mesotherapy services.​

While mesotherapy may offer aesthetic benefits for some individuals, the procedure is not without risks, particularly when performed outside of a clinical setting or by untrained individuals. The lack of regulatory oversight and standardized formulations further complicates the safety profile of this treatment. Prospective patients should exercise caution, seek professional medical advice, and thoroughly research practitioners before considering mesotherapy.

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